Functional Consequences of Human Induced Pluripotent Stem Cells Therapy: Myocardial ATP Turnover Rate in the in vivo Swine Hearts with Post-Infarction Remodeling
نویسندگان
چکیده
Ad Addr dres ess s fo for r Co Corr rres espo pond nden ence ce: : Abstract: Background—The use of cells derived from hiPSCs as cellular therapy for myocardial injury
منابع مشابه
Functional consequences of human induced pluripotent stem cell therapy: myocardial ATP turnover rate in the in vivo swine heart with postinfarction remodeling.
BACKGROUND The use of cells derived from human induced pluripotent stem cells as cellular therapy for myocardial injury has yet to be examined in a large-animal model. METHODS AND RESULTS Immunosuppressed Yorkshire pigs were assigned to 1 of 3 groups: A myocardial infarction group (MI group; distal left anterior descending coronary artery ligation and reperfusion; n=13); a cell-treatment grou...
متن کاملHuman Induced Pluripotent Stem Cell-Derived Cardiomyocyte Encapsulating Bioactive Hydrogels Improve Rat Heart Function Post Myocardial Infarction
Tissue engineering offers an exciting possibility for cardiac repair post myocardial infarction. We assessed the effects of combined polyethylene glycol hydrogel (PEG), human induced pluripotent stem cell-derived cardiomyocyte (iPSC-CM), and erythropoietin (EPO) therapy in a rat model of myocardial infarction. PEG with/out iPSC-CMs and EPO; iPSC-CMs in saline; or saline alone was injected into ...
متن کاملLarge-Scale Expansion of Human Embryonic and Induced Pluripotent Stem Cells for Cell Therapy Applications
Successful isolation, derivation and culturing of human pluripotent stem cells, including human embryonic stem cells (hESCs) and human induced pluripotent stem (hiPSCs) cells in laboratory scale has opened new horizones for cell therapy applications such as tissue engineering and regenerative medicine. However, most of the cell therapy protocols using these unique cells require large number of ...
متن کاملThe Structural Basis of Functional Improvement in Post-Infarct Rat Hearts with Stem Cell Treatment
Myocardial infarction (MI) is one of the major causes of heart failure in the world. Due to the loss of viable myocardium and high myocardial wall stress after MI, the heart undergoes progressive remodeling that will eventually lead to heart failure. Recently, cellular transplantation using stem cells has been proposed as a treatment strategy for preserving the myocardium in infarct area and bo...
متن کاملInduced pluripotent stem cells (iPSCs) based approaches for hematopoietic cancer therapy
Induced pluripotent stem cells (iPSCs) are reprogrammed from somatic cells through numerous transcription factors. Human induced pluripotent stem cell approaches are developing as a hopeful strategy to improve our knowledge of genetic association studies and the underlying molecular mechanisms. Rapid progression in stem cell therapy and cell reprogramming provides compelling reasons for its fe...
متن کامل